1, recurrent cholecystitis symptoms: that is, greasy food is prone to induce recurrent epigastric pain, often requiring medication and infusion treatment, recurrent attacks to patients’ lives and work bring great impact, often the cumulative cost of drug and infusion treatment is often much higher than a surgical solution to the problem. These patients often end up needing surgery to completely solve the pain caused by gallbladder stones. 2, gallbladder atrophy: chronic stone atrophic cholecystitis is often the result of gallbladder stones causing recurrent attacks of cholecystitis symptoms, or the occurrence of a severe acute cholecystitis. The atrophied gallbladder is often non-functional or basically non-functional, it is just a lesion, many atrophied gallbladder is just a packet of stones wrapped around the gallbladder, this atrophied gallbladder even if the painful symptoms of cholecystitis do not occur, but because of the high risk of cancer, therefore must be surgically removed. 3.Long history of gallbladder stones: If it is 10 years or even 20 years, or if the gallbladder stones are large, with a diameter of 3cm or more, surgery should be performed because of the high risk of gallbladder cancer caused by long-term stone stimulation and stones of 3cm or more. 4.B ultrasound or CT found calcification of gallbladder wall: medically known as “porcelain gallbladder”, which is a kind of precancerous lesion and needs surgery. 5.Gallbladder stones combined with gallbladder polyps: early surgery should be performed to prevent polyps from becoming cancerous. 6.B ultrasound or CT found that the gallbladder wall is obviously thickened: especially a certain localized thickening, the thickened part may be cancerous and needs to be operated as soon as possible. 7, gallbladder stones have been discharged into the common bile duct causing liver function damage: or biliary pancreatitis, even if the stones in the common bile duct are found to be no longer present, gallbladder stones still need to be treated surgically to prevent stones from being discharged again causing common bile duct stones and biliary pancreatitis. Women who are planning to get pregnant: If gallbladder stones are found before pregnancy, especially for women who have already had an attack, it is recommended to perform cholecystectomy first and then get pregnant after six months. Because pregnant women need to eat a variety of nutrient-rich foods, such as eggs, large meat, etc., these foods may induce biliary colic, and if the diet is controlled, it may have an impact on fetal nutrition. And when gallbladder stones attack in pregnant women, they must be treated. If treated conservatively, medication may cause effects to the fetus, and if treated surgically, the surgery may cause miscarriage or premature birth. 9. Patients with gallbladder stones combined with: diabetes, hypertension, heart disease, emphysema and other diseases, and have reached the age of 60 years or more, but the current physical condition is still able to withstand gallbladder surgery. It is difficult to bear the surgery. Although there are certain risks associated with surgical treatment, cholecystectomy is now a very mature procedure with low risk and less trauma, especially laparoscopic cholecystectomy. Patients with gallbladder stones are advised to seek consultation with a specialist in hepatobiliary surgery to guide and select treatment options.