Clinically, the drug of choice for the treatment of syphilis is long-acting penicillin, but long-acting penicillin is usually administered intramuscularly and intravenously, and oral penicillin is not used to treat syphilis. For syphilis patients who are allergic to penicillin, tetracycline, macrolides and ceftriaxone can be used instead. Tetracycline and macrolides can be taken orally to treat syphilis, but patients should never take antibiotics at home to treat syphilis because they are afraid that others will know they have syphilis. In addition to the application of antibiotics, the treatment of syphilis also requires close monitoring of the changes in one’s titer, and the use of antibiotics needs to be regulated according to the changes in the titer. In clinical practice, patients can generally stop observation when their titer is controlled at about 1:4, and they need to go through a relatively long clinical titer observation period.