Ankylosing spondylitis, is a disease in which inflammation of the sacroiliac joints and spinal attachment points is the main symptom. Ankylosing spondylitis is strongly associated with HLA-B27 and thus has some heritability. Ankylosing spondylitis occurs mostly in young and middle-aged men, and the cause and pathogenesis are unclear. In the early stage of the disease, patients often feel weakness, loss of appetite, low fever, and emaciation, and these symptoms lack typicality and are easily ignored. With the development of the disease, patients often feel pain and stiffness in the lumbosacral region, which is especially obvious in the morning, and many patients even have difficulty sleeping due to pain in the early morning hours, but this pain will be reduced with activities. If treatment is not timely, the pain in the lumbosacral area will gradually increase and the area will expand to the thoracic and cervical spine and to the entire spinal joint, and ankylosing deformities of the spinal joint will gradually appear. In addition, patients with ankylosing spondylitis may develop extra-articular manifestations such as heart valve lesions, ocular conjunctivitis, iritis, uveitis or uveitis. Ankylosing spondylitis treatment is based on drug therapy, anti-inflammatory painkillers, immunosuppressants, biological agents are more widely used, Chinese herbal medicine also has a certain role.