The development of ankylosing spondylitis is mainly related to genetics and the environment. Often, siblings or other relatives of people with ankylosing spondylitis are found to have the same disease. The disease has a high rate of HLA-B27 positivity. In the early stages of the onset of ankylosing spondylitis most patients just feel pain in the lower back, and in severe cases spinal function is affected. In the middle stages, pain in the joints of the lower back and lower limbs is evident, and functional movement of the spine is limited or even partially ankylosed. At this time, if timely diagnosis and correct treatment, most patients can obtain good results. If the disease develops to an advanced stage, spinal ankylosis or hunchback deformity will lose the time for treatment. The disease is often difficult to cure. Therefore, early diagnosis and early treatment are emphasized. Ankylosing spondylitis belongs to the category of “paralysis” in Chinese medicine, and the principle of treatment for this disease is to “support the righteousness and dispel the evil, and benefit the kidneys and the governors”. It can be treated internally with Chinese medicine, externally with Chinese medicine fumigation, and with acupuncture, moxibustion, and massage. Up to now, I have carried out the treatment methods such as penetrating acupuncture therapy, moxibustion and fire therapy with medicinal wine. The effect is satisfactory, not only can relieve the clinical symptoms, persistent treatment can also control the development of the disease, and finally achieve complete recovery. The last point to emphasize is: young men, encounter unexplained lumbar, knee, hip pain, heel pain, to go to the hospital’s rheumatology and immunology department in order to early detection, early diagnosis, early treatment, so as not to delay the timing of treatment, and finally lifelong regret!