Ankylosing spondylitis is an inflammatory disease of the spine. The disease mainly involves the spine’s predominant mid-axis structure, which can cause a series of functional and organic damage such as pain, stiffness and muscle fatigue, which in turn can limit the patient’s spinal movement and cause a lot of inconvenience to the patient’s working life. Evidence-based medicine suggests that rehabilitation exercises are the most important part of AS treatment. Although the efficacy of rehabilitation exercises and aerobic exercise has been mentioned in the literature, the details of what kind of exercises patients should take, how many times per week and how long each exercise should be are still unknown. In order to investigate the changes in motor function, spinal mobility, disease progression and quality of life in AS patients after aerobic exercise, Dr. Jennings et al. of the University of Sao Paulo, Brazil, conducted a 12-week randomized controlled trial and published the results in the journal JRheumatol, hoping that physicians and patients would have a more accurate and specific understanding of the effects of aerobic exercise. It is hoped that physicians and patients will have a more accurate and specific understanding of the effects of aerobic exercise and thus be more aggressive in their treatment. A total of 70 patients with AS were enrolled in this trial. All patients were clearly diagnosed according to the modified New York criteria and had been receiving standardized medication, and none of the patients participating in this trial had any prior medical conditions that could affect the outcome of the trial, such as diabetes or cardiovascular disease. Seventy patients were unknowingly divided equally into a test group and a control group of 35 patients each. During the 12 weeks of the trial, the patients in the test group performed three sets of 30 seconds each, in addition to stretching exercises three times a week, which required the patients to fully stretch their trunk and limb muscles. In addition, each stretching session was preceded by 50 minutes of aerobic exercise, which consisted of a 5-minute warm-up – a 40-minute walk (the patient’s anaerobic threshold heart rate was measured beforehand and the patient’s heart rate was always below the anaerobic threshold heart rate during the walk) – and a 5-minute rest. minutes of rest. In contrast, patients in the control group performed only stretching exercises. Patients were evaluated before the start of the trial (T0), 6 weeks after the start of the trial (T6), at the end of the trial (T12) and 12B weeks after the end of the trial (T24) with a full assessment of spinal function (a combination of BASFI, HAQ-S and 6-minute walk test results). A spinal mobility assessment (BASMI), a disease activity assessment (also measuring BASDAI/ASDAS scores, CRP levels and sedimentation), and a quality of life assessment (SF-36) were performed. After the trial, it was found that the BASFI, HAQ-S, BASAMI and ASDAS scores were substantially higher in both the test and control groups, and the difference between the two groups was not significant. However, the 6-minute walking distance of the patients in the test group was significantly greater than that of the control patients. Also, the cardiopulmonary function of the patients in the test group was significantly better than that of the control group. Based on these results, the researchers concluded that aerobic exercise, in addition to stretching, does not improve spinal function and mobility, nor does it delay the progression of the disease, but it does increase the walking distance and improve the cardiopulmonary function of patients with AS. Therefore, appropriate aerobic exercise in addition to regular rehabilitation would be beneficial for patients with AS.