In modern society, gallbladder stone disease has become a frequent and high incidence due to the high-fat diet and the change in lifestyle habits (late to bed and early to rise). Some scholars have observed that 50% of asymptomatic patients will develop symptoms later, and patients over 60 years old have a higher chance of developing complications, with a mortality rate as high as 15%, which is even more dangerous if combined with diabetes and hypertension. Moreover, there is a relationship between gallbladder cancer and gallbladder stones, and 60%-92% of gallbladder cancer patients have gallbladder stones. Therefore, elderly patients with asymptomatic gallbladder stones are best treated with elective surgery, that is, surgery without abdominal pain. In addition, some of the elderly patients with asymptomatic gallbladder stones suffer from myocardial ischemia, and when gallbladder stones cause biliary angina, heart disease can be induced by the bile-heart reflex. Such patients should be treated surgically for gallbladder stones when their cardiac function can tolerate it, in favor of focusing on coronary artery disease. In terms of treatment, mechanical lithotripsy or pharmacological lithotripsy is not recommended, but many people in China have the misconception that gallbladder stones can be “knocked out” or “melted away”, because once the stones enter the common bile duct, they can cause acute septic obstructive cholangitis and biliary origin cholangitis. Once the stone enters the common bile duct, it can cause acute suppurative obstructive cholangitis and biliary pancreatitis, which are much more risky than simple gallbladder stones. Drug lithotripsy lacks ideal drugs, and the current drugs have a long course, poor efficacy, and large side effects. The current endoscopic minimally invasive biliary stone retrieval is a good method. This treatment uses a combination of laparoscopy and cholangioscopy to retrieve stones, which has a short operative time and few postoperative complications, and can not only remove stones minimally invasively but also preserve the gallbladder, however, this method is only for patients with normal gallbladder function and completely asymptomatic, otherwise the recurrence rate of stones is extremely high, which is not worth the loss. However, it is controversial whether it is appropriate even for elderly people with normal gallbladder function, and it is widely believed that biliary stone extraction is not recommended for the elderly. Laparoscopic cholecystectomy is a good option because the gallbladder wall is inflamed and gallbladder function is lost along with the development of stones. Our department performs single-hole (only one incision in the umbilicus) and micro-hole (incision only the size of a soybean) laparoscopic cholecystectomy with great proficiency and less trauma which is believed to bring more benefits to the majority of elderly patients.