At present, the treatment of chronic hepatitis B is a worldwide problem. Many chronic hepatitis B patients have been treated with many kinds of medicines, but the efficacy is not obvious, and the condition is always recurring. The reason why chronic hepatitis B has become a persistent disease is closely related to the structure of hepatitis B virus, replication characteristics, mode of infection, immune characteristics and other factors. 1.Hepatitis B virus has a complete protein shell, it is difficult for drugs for treating hepatitis B to have a direct effect on the virus, and it is necessary to rely on the body’s immune function to kill the liver cells in order to remove it. 2, the replication of hepatitis B virus is carried out in the liver cells, and therapeutic drugs to enter the liver cells to play an antiviral effect, so antiviral drugs to play a role, there must be a sufficient course of treatment, sufficient dose. 3.The target position of anti-hepatitis B virus drugs used at present is mostly below the level of super-helical DNA (cccDNA) of hepatitis B virus, and there is no inhibition and degradation of cccDNA. Therefore, no matter what anti-viral drugs are used, as long as there is a small amount of cccDNA in hepatocytes, the cccDNA in the nucleus can become the “template” of viral replication once again when the drugs are discontinued. “So no matter what antiviral drugs are used, as long as there is a small amount of cccDNA in the liver cells, when the drugs are stopped, the cccDNA in the nucleus can become the template of virus replication again and continue to replicate the DNA of hepatitis B virus. Hepatitis B virus under the action of certain drugs or in the state of natural selection, viral gene mutation will occur, resulting in drug resistance or immune evasion. After hepatitis B virus infects liver cells, it is possible that the virus will integrate with the genes of liver cells. Once this phenomenon occurs, if the liver cells do not die, the virus will not die, and the difficulty of treatment will be significantly increased. It is these factors that lead to the infection of hepatitis B virus, a variety of targeted methods are always a long course of treatment, the effect is not satisfactory. Therefore, all patients must not be gullible to all sorts of wandering doctor’s all sorts of fooling, but to have patience for the treatment of hepatitis B, have perseverance, do not be in a hurry to cut into, resulting in the loss of money, the condition can not get better.