I. Symptoms of syphilis Stage I syphilis mainly manifests as a single or several shallow ulcers near the genitals, or enlarged inguinal lymph nodes, but a significant proportion of patients have no symptoms and go straight to the next stage. The rash of stage II syphilis is a universal imitator, it can resemble any skin disease and the diagnosis still requires the experience of a specialist, but of course there is still a significant proportion of people who have no symptoms at this time. Stage III syphilis About 40% of untreated syphilis patients can develop active late syphilis, which can invade any of the organs such as joints, bones, eyes, cardiovascular and nervous system in addition to skin and mucous membrane manifestations, seriously endangering the health of patients. Second, pregnancy syphilis and congenital syphilis Not syphilis pregnant women can not produce. The syphilis spirochete is not transmitted to the fetus through the placenta 5 years after the woman herself is infected with syphilis. In patients with current syphilis, the syphilis spirochete cannot pass through the placental barrier during the third month of pregnancy, and as long as they receive regular syphilis treatment at this time, more than 95 percent of pregnant women can give birth to healthy babies. Of course, if you miss this time, you can still treat the fetus during the 7th-9th months of pregnancy. As long as there is no serious organ damage in congenital syphilis patients, if they are only serologically positive, regular antisyphilis treatment after birth is often very effective. The actual syphilis is transmitted 95% of the time through sexual relations, mother to child and blood. Because the semen, vaginal secretions, saliva, milk, rash and mucous membrane exudate, blood and even sweat of syphilis patients contain enough infectious amount of syphilis spirochetes, so syphilis is more infectious than hepatitis B, C, AIDS, etc., more ways of transmission. It is not uncommon for people to become infected through close contact with patients, such as breastfeeding, kissing, or using utensils or household items contaminated by patients (body fluids, blood and secretions). It is also not uncommon for medical personnel to become infected with syphilis themselves because of occupational exposure. At present, the spread of syphilis has spread to the general population. The treatment of syphilis is the standard treatment of syphilis, it is reported that early syphilis after the standard adequate treatment, about 90% of early patients can achieve the purpose of eradication, and the earlier the effect of treatment, the better. It should be emphasized that syphilis should not be treated indiscriminately, because only 25% of untreated early syphilis end up with serious damage, while 35%-40% of those who receive inappropriate treatment have worse results than those who are not treated, indicating that irregular treatment can increase recurrence and promote the early occurrence of late damage. Penicillin is still the drug of choice for all stages of syphilis.