It is well known that Botox is one of the most commonly used methods for facial wrinkle reduction by injection. The use of Botox, its wrinkle-reducing effects, onset of action time, and side effects have been extensively studied. Recent new research has shown that Botox has some therapeutic effects on depression while removing frown lines. The frown muscle is important in expressing negative emotions such as sadness, fear, anger, and distress. In contrast, Botox injections for interfrown lines work by paralyzing the patient’s frown muscles and stretching the tightly locked frown. The feedback effect on the face suggests that facial muscle paralysis not only affects the patient’s expression, but also, can have a subtle effect on the patient’s mood. Just as paralysis of the laughing muscles makes it difficult to maintain a happy expression, paralysis of the frowning muscles makes it difficult to maintain an unpleasant mood, thus reducing the incidence of depression. As a result, experts have proposed that depression can be treated along with botulinum toxin removal of frown lines. A study presented at the 72nd Annual Meeting of the AAD showed that Botulinum toxin type A injections have antidepressant effects. The study, conducted by Michelle Magid, M.D. (associate professor of clinical psychology) and her husband Jason Reichenberg, M.D. (associate professor of dermatology) at the University of Texas Southwestern Medical Center, is summarized as follows: 1. 30 patients with depression participated in the trial for 24 weeks in a randomized, double-blind, placebo-controlled trial: one group received placebo treatment first, followed by interbrow botulinum toxin injections 12 weeks later; the other group received interbrow Botox injections, followed by placebo treatment 12 weeks later …… 2. The results found that interbrow botulinum toxin type A injections had their antidepressant effect and that the antidepressant effect persisted even after the wrinkle-reducing effect of botulinum toxin wore off-that is, the The cosmetic effect of botulinum toxin is not the only factor contributing to its antidepressant effect. Behavioral effects: The cosmetic effects of Botox can improve interpersonal social interactions, self-esteem and mood, thus achieving antidepressant effects; biological effects: The facial trigeminal nerve transmits sensory information to the amygdala (which is often associated with emotions such as fear, depression and anxiety). The effect of Botox on anxiety and depression is improved. 4. This preliminary finding has yet to be confirmed in larger pilot studies before it can be applied to the clinical treatment of depression.