Patients with depression who are denied systemic medication, which is considered by doctors to be very important, are often encountered in our clinic and cause headaches for doctors. So, what is systematic medication for depression? 1.Diagnosis should be clear First of all, we should identify whether it is depression or anxiety, if it is anxiety, psychotherapy and active self-adjustment of patients are important. If it is depression, mild depression can be considered only psychotherapy, and those who are not suitable for psychotherapy should be medicated; if it is severe depression, it must receive medication. Severe depression is subdivided into major depression and bipolar depression, the former is treated mainly with anti-inhibitory drugs, the latter is treated mainly with emotion stabilizers and can be treated with auxiliary anti-depressants if necessary. The differential diagnosis of major depression and bipolar depression is also important. If bipolar depression is treated as major depression, mania, mixed episodes or rapid cyclic states are easily induced, leading to complication, increased treatment difficulty and increased suicide rate. Clinically, most of the patients with genius depression like Lin Jiawen are bipolar depression or potential bipolar depression, and depression with hallucinatory delusions, depression with multiple suicidal behaviors and refractory depression are also mostly bipolar depression. Once a professor from the Chinese University of Hong Kong came to Guangzhou for an exchange, he said that more mainland university students studying in the Chinese University of Hong Kong suffered from bipolar depression, and almost all of these children were the top students in the entrance exams of various provinces and cities. 2, adequate dosage and full course of treatment First, the dosage of drugs should be sufficient, patients and patients’ families must not reduce the dosage of drugs without authorization; second, the course of treatment should be sufficient, the whole course of treatment includes the acute treatment, consolidation treatment and maintenance treatment 3 stages. It is not allowed to take sometimes and sometimes not, or to stop the medication prematurely. Clinically, the failure to achieve the full amount and course of treatment is one of the main reasons for fluctuations or recurrence of the disease. 3.Regular follow-up Severe depression, especially bipolar depression, is a condition that changes rapidly and requires regular visits to the doctor so that the doctor can detect changes in the condition and adjust the treatment plan in time. If the patient or family members find that the condition has worsened, they must see the doctor in advance. 4, family members should actively cooperate with the doctor system treatment, close friends can also help One is to understand, accompany and support the patient; two is to monitor the patient to take drugs on time and in the right amount, and urge the patient to see the doctor regularly; three is to closely observe the changes in the patient’s condition and response to treatment, and promptly tell the doctor. Patients often unconsciously send out some distress signals before committing suicide, when the patient’s family and close friends around them should be alert, for example, Lin Jiawen had sent books to his teacher before he committed suicide, and frequently talked to his friends about death and other abnormal behavior. 5, about psychotherapy For severe depression, psychotherapy is not the main treatment, but only as an auxiliary treatment. A recent study showed that for bipolar depression, psychotherapy and active mental health education are equally effective. 6.Actively self-adjustment Regular work and rest, no late nights, getting up on time every day, moderate work and exercise, no alcohol, less coffee and tea, etc., these daily precautions are also important.