The hepatobiliary surgery department successfully performed laparoscopic drainage of a giant cyst in the spleen on a 17-year-old patient, who recovered well and was discharged 7 days after surgery and resumed normal school life. The patient, a sophomore in high school, had a bulging upper abdomen for nearly a year, with significant fullness after eating, and a round mass the size of a child’s head could be felt; CT and ultrasound revealed a cystic mass of nearly 20 cm in size in the spleen, and the liver, stomach and kidney were obviously compressed. This patient was the first case of cystic occupancy of the spleen admitted to our hospital. Through literature review, we learned that this disease is rare, and only two medical institutions in China have reported several cases, except for a minimally invasive treatment at the Second Military Medical University, all of which used traditional open splenectomy. will be affected. The medical and nursing staffs of hepatobiliary surgery teamed up, repeatedly reviewed information and consulted several sister units. After thorough discussion and preparation, the patient decided to perform laparoscopic splenic cyst opening and drainage after excluding splenic worm disease. Director Li Hucheng, in close cooperation with Deputy Director Liu Xiuzhen of the Department of Anesthesiology, used only two 1cm and two 0.5cm incisions in the patient’s abdomen to completely drain 3500ml of fluid from the cyst, and at the same time cut down the wall of the cyst about 10×8cm2 in size to open the window of the cyst and perform pathological examination, which indicated a benign epithelioid cyst. The patient recovered smoothly after the operation and got out of bed the same night after the operation, and started to eat on the first morning. Three days after the operation, the drainage tube was removed and the diet and activities returned to normal. 7 days after the operation, ultrasound and CT examination indicated that the cyst cavity had shrunk significantly and the spleen had basically returned to normal size, and the liver function and blood routine were completely normal. Microscopic puncture of the cyst to extract part of the cystic fluid Laparoscopic spleen cyst opening and drainage gave full play to the advantages of minimally invasive laparoscopic technology such as small trauma, quick recovery and clear anatomy, which preserved the function of the spleen and achieved an aesthetic effect. The successful implementation of this operation brought our minimally invasive technology to a new level and made a useful attempt to carry out laparoscopic splenic surgery in the future.