The initial symptoms of syphilis may start to appear after 3 weeks. The early stages of the disease have no obvious symptoms and can be divided into 3 stages according to their development: stage 1, stage 2, and stage 3/late. Syphilis is a highly contagious sexually transmitted disease caused by the syphilis spirochete. The symptoms usually begin after the first 3 weeks of syphilis infection and become a hard chancre, which is a small, hard, round and painless sore or sores in the coronal groove of Shoin. The sores appear where the virus enters the body, such as the shoin, foreskin, shoin lips, mouth, genitals and anus. Syphilis Stage II usually occurs about 2 months after the initial infection and is characterized by “macules” on the palms of the hands and feet, which are usually not itchy and have rough, reddish-brown spots on the skin. Syphilis stage III can be more severe, causing damage to the brain, heart, eyes, liver, bones and joints, and in severe cases can lead to death. Symptoms include difficulty with muscle movement, numbness, paralysis, progressive blindness and dementia. If unusual discharge, ulcers or rashes appear in the genital area, it is recommended that a timely syphilis monitoring be done at the hospital to rule out that if left untreated, it can cause irreversible damage to body tissues.