If the transmission of syphilis is divided into five ways, it can include sexual transmission, vertical transmission from mother to child, horizontal transmission from mother to child, blood transmission and indirect contact transmission, where vertical transmission from mother to child and horizontal transmission from mother to child can also be collectively called mother-to-child transmission. The main way of transmission is sexual transmission, early invasion of the skin and mucous membranes, late invasion of the cardiovascular and central nervous system, can be divided into acquired syphilis and congenital syphilis. 1, sexual transmission: is the common mode of transmission of syphilis, mainly occurs during intercourse, rapid congestion of the genitalia, friction will cause skin and mucous membrane damage, the infected person with The infected person with the pathogen body fluids contacted the infected person broken mucous membrane, so that the syphilis spirochete into the body and transmission occurs. In addition, also includes abnormal sexual behavior, contact to damage to the lips, anus, fingers and other parts of the patient will also show syphilis infection; 2, mother and child vertical transmission: If the mother has syphilis, and not timely treatment, the mother’s syphilis spirochetes can be directly transmitted to the fetus through the placenta blood, resulting in fetal syphilis infection, may appear stillbirth, premature birth, etc.. After delivery, the fetus may appear thin and small, with pale, loose skin and a low cry, and vertical mother-to-child transmission through the placenta mainly occurs in pregnant women with early syphilis; 3. Horizontal mother-to-child transmission: If the mother is infected with syphilis and has a head or shoulder abrasion when the fetus is delivered through the birth canal and comes into contact with the mother’s blood, the newborn may develop syphilis. Shortly after birth or within 1-2 months after birth, newborns are found to have poor development and nutrition, especially in premature babies, often showing symptoms such as emaciation, fever, crying and restlessness, dehydration, etc.; 4. Blood transmission: If a patient with latent syphilis acts as a blood donor, or if the blood provided by a patient with syphilis infection contains pathogens, when fed into the recipient, it is very easy for the recipient to become infected with syphilis, and the recipient generally does not The recipient does not usually develop stage 1 syphilis. Therefore, it is recommended that blood donors should be screened for syphilis spirochetes in a timely manner to avoid transmitting the pathogen to healthy blood recipients through blood; 5. Indirect contact transmission: If healthy people live with syphilis patients, they cannot avoid indirect contact with underwear, bedding, towels and other household items. These supplies may be contaminated by syphilis spirochetes contained in the body fluids of infected people, resulting in healthy people being infected with syphilis through indirect contact. If the patient or the fetus shows some abnormal symptoms, it is recommended to go to the hospital for relevant examinations, such as blood test for syphilis antibody and titer, or dark-field microscopic examination, syphilis serological test, etc. for clear diagnosis. Under the guidance of the doctor, choose antibiotics for treatment according to the condition, such as penicillin, erythromycin, tetracycline, etc.