The murder of her husband Wang Xiaoye by Chinese-American chemist Li Tianle using the heavy metal thallium reminds us again of the thallium poisoning of a Tsinghua girl. The bizarre thallium poisoning left the multi-talented Zhu Ling with total body paralysis, 100% disability and brain retardation, while the murderer got away with it. The reason why the chemist poisoned and killed her husband was speculated by netizens as not wanting to get a divorce. It turns out that there is a poison called thallium poisoning. Thallium is a toxic heavy metal that is used in industry to make photocells, alloys, low-temperature thermometers, pigments, dyes, and fireworks. Thallium bromide and thallium iodide are the raw materials for manufacturing infrared filter glass. Thallium sulfate can make insecticide and rodenticide. Thallium acetate, thallium iodide, and thallium sulfate have been used as hair loss agents and to treat ringworm of the head. The therapeutic amount of thallium preparation is very close to the lethal amount of poisoning, so it is very easy to cause poisoning. Thallium is a strong neurotoxin and has damaging effects on liver and kidney. Acute poisoning can be caused by inhalation and oral administration; it can be absorbed through the skin. Acute poisoning: There is a certain incubation period, and the length of the incubation period is related to the dose of exposure, and the symptoms usually appear 12 to 24 hours after exposure. Chronic poisoning: The onset is slow and the clinical manifestations are basically similar to those of acute thallium poisoning. Early manifestations are neurological-like symptoms such as headache, dizziness, drowsiness, insomnia, dreaminess, memory loss, lethargy and weakness. Subsequently, hair loss, such as baldness or total baldness, may occur. In addition, there may be loss of appetite, vomiting, abdominal pain, and diarrhea. Loss of vision is a prominent manifestation, and in severe cases, only light perception is present. The fundus of the eye shows retinitis, retrobulbar optic neuritis, and optic nerve atrophy. Sometimes peripheral neuropathy occurs, showing numbness, pain, limb sensation and motor disorders in both lower limbs. Some patients may have hypothermia, tachycardia, precordial pain, hypertension, hepatomegaly, skin pigmentation, nail Mees lines. Treatment: Prussian blue: Prussian blue is a non-toxic pigment that has significant efficacy in acute and chronic thallium poisoning. The mechanism of action is that thallium can replace potassium on Prussian blue to form Prussian blue-thallium complexes excreted in the feces. The dosage of Prussian blue is generally 250mg/kg per day, divided into 4 doses, each time dissolved in 15% mannitol 50ml; the duration of administration can last until the 24h urinary thallium content is less than 0.5mg. The administration is accompanied by magnesium sulfate to induce diarrhea. The drug has no side effects and both fecal and urinary thallium are excreted during treatment, and fecal thallium exceeds urinary thallium. There is no rebound after treatment. For severe poisoning cases, the use of hemoperfusion is more effective than hemodialysis, because thallium is mainly distributed in cells and less in blood, if hemodialysis and hemoperfusion are combined, the effect is better.