One very important reason why chronic kidney disease is easily overlooked is that its early stages can be completely asymptomatic or have mild and insignificant symptoms. However, as the disease progresses, patients can gradually develop different degrees of symptoms. 1.How are the early symptoms of chronic kidney disease? In the early stage of chronic kidney disease, patients can experience easy fatigue, weakness, sometimes edema of the eyelids, face, lower limbs, especially near the ankles, abnormal urine color, large amount of foam in the urine, sometimes difficulty and pain in urination, and increased number of urination at night. 2. Development and deterioration of chronic kidney disease. In when the disease progresses to renal insufficiency or even uremia, patients will often have symptoms of various systems. Such as will appear gastrointestinal symptoms such as loss of appetite, morning sickness and vomiting. Blood pressure system symptoms such as anemia and bleeding tendency may occur. Respiratory symptoms such as pulmonary congestion and pulmonary edema, uremic pleurisy, etc. may occur. Neuromuscular symptoms such as central nervous system dysfunction, inattention, drowsiness, and insomnia can occur. Skin manifestations such as pruritus can occur. Skeletal system manifestations such as renal bone disease or renal-shaped osteodystrophy may also occur. In addition, there will be various manifestations such as endocrine metabolism disorder, infection, metabolic acidosis, water-electrolyte balance imbalance, etc. 3.What are the common complications of chronic kidney disease? It is important to note that chronic kidney disease is often combined with cardiovascular complications, such as hypertension and left ventricular hypertrophy, coronary atherosclerosis and peripheral vascular disease, congestive heart failure, pericarditis and other complications. Why does chronic kidney disease combine with coronary atherosclerosis? That is because hypertension, hyperhomocysteinemia and disorders of lipid metabolism promote the development of atherosclerosis, while the patient’s combined hypercoagulable state also promotes the development of thrombotic disease. In addition the metastatic calcification of blood vessels caused by disorders of calcium and phosphorus metabolism also significantly increases the occurrence of occlusive vascular diseases of coronary vessels, cerebral vessels and peripheral vessels.