Chronic kidney disease stage IV is more serious, and if in chronic kidney disease stage IV, patients should be prepared for kidney replacement therapy related to it. Because chronic kidney disease stage IV may progress to uremic stage in a short time. Chronic kidney disease stage IV is defined as glomerular endogenous creatinine clearance between 15-29mL/min. In normal people, the glomerular filtration rate is between 80-120mL/min. Stage IV chronic kidney disease is equivalent to the glomerular filtration rate has decreased by 3/4, which means 3/4 of the kidney function has been broken, and only 1/4 of the kidney is left good. Patients with chronic kidney disease stage IV period need to mention treatment related complications. Chronic kidney disease stage IV will not only develop to the uremic stage, but also all kinds of complications, such as anemia, hypertension, heart failure, internal environment disorders, such as hyperkalemia and metabolic acidosis, etc. It will also be combined with serious complications such as ulcers in the digestive tract and even bleeding.