The onset of chronic kidney disease is caused by a combination of factors, and the incidence is increasing year by year, which has increasingly attracted the attention of the medical community. However, chronic kidney disease is often overlooked by patients and doctors, not easily detected at an early stage, or even missed diagnosis and miss the best time for treatment and intervention. So why is it difficult to detect chronic kidney disease at an early stage? Firstly, chronic kidney disease can be completely asymptomatic or without obvious symptoms in the early stage, so patients and their families can easily ignore it, and when foam and anemia are found in the urine, it is often in the late stage of chronic kidney disease. Secondly, the current methods of kidney function tests have certain limitations, and the general urine routine and blood creatinine tests cannot detect early chronic kidney disease. And the glomerular filtration rate (eGFR) recommended by international guidelines is more difficult to carry out in non-nephrology departments. Again, the poor education of kidney disease science, poor disease awareness among high-risk groups, lack of attention to kidney health, lack of knowledge of kidney disease, and inability to seek early diagnosis. And if chronic kidney disease is not prevented and treated early, the disease will gradually progress. Many patients often find that kidney function has developed to a serious stage when they first go to the hospital, missing the best time for treatment, the condition will be difficult to reverse and develop to uremia, which will greatly endanger the health and life of patients and increase the burden of family and society. Therefore, both doctors and patients should pay attention to the early detection and diagnosis of chronic kidney disease and the detection of eGFR. For patients with existing chronic kidney disease, early treatment can significantly delay the deterioration of kidney function, postpone the time to enter dialysis, improve the quality of life, and reduce the burden of family and society.