In the end stage of chronic renal failure, the decline in renal function often leads to decreased phosphorus excretion, decreased calcium reabsorption and decreased secretion of active vitamin D3, resulting in disorders of calcium and phosphorus metabolism, often manifesting as low calcium and high phosphorus, which in turn leads to increased secretion of parathyroid hormone, resulting in secondary hyperparathyroidism. Secondary hyperparathyroidism can also lead to hypertransformational bone disease, also known as hyperparathyroid bone disease, which is mainly seen in patients with chronic renal failure with hyperparathyroidism. In addition to a significant increase in parathyroid glands, there is a significant increase in calcium, phosphorus and alkaline phosphatase.