Syphilis has now become a common clinical disease and doctors are no longer unfamiliar with basic treatment, however, after treatment, how to determine whether it is cured? At present, syphilis serological tests are usually applied to determine, and the more commonly used ones at all levels of hospitals are RPR (rapid plasma reactin ring card test) and TPHA (syphilis spirochete hemagglutination test). The RPR is a non-specific syphilis serological test, often used for the early diagnosis of syphilis, but not sensitive to latent syphilis, neurosyphilis. TPHA detects serum-specific syphilis spirochete antibodies, with high sensitivity and specificity. The latter, once positive, usually remains positive for life regardless of treatment or disease activity, and titer changes are not related to syphilis activity, so it cannot be used as an indicator to evaluate the efficacy or determine recurrence and reinfection, but can only be used as a confirmation test for syphilis. 2.Cure standard The quantitative test should be done before syphilis treatment. The difference between the two quantitative test titers is more than 2 dilutions before the titer is judged to have decreased. The RPR titer should be rechecked once a month for the first three months after regular treatment, and then every three months for the next year, and every three months or every six months for the second year, in order to observe and compare the changes in RPR titer between the current and previous times. Therefore, the follow-up observation of syphilis patients after treatment is usually over a period of two years. If the RPR titer of each test shows a decreasing trend, it indicates that the anti-syphilis treatment is effective. If the results of three to four consecutive tests are negative, the patient is considered to be cured of syphilis. 3.Types of serum changes after treatment After anti-syphilis treatment, there are generally 3 possible changes in its serum response: (1) Serum negative. (2) Serum titer reduction without negative transformation, or serum resistance. (3) Serologic response indicating relapse. 4. Differences in serologic response The rate of negative serologic response varies among stages of syphilis treated with different drugs. In early syphilis treated with any anti-syphilis drug, the seronegative rate is high, usually up to 70%-95% within 1 year, with individual reports up to 100%. When seropositivity is maintained 6 months after regular anti-syphilis treatment for early syphilis or 12 months after regular anti-syphilis treatment for late syphilis, it is clinically referred to as “seroresistance” or “serofixation”, which may be related to the presence of potentially active lesions in the body. This may be due to the presence of underlying active lesions, persistent immunity of the patient, inadequate dose of anti-syphilis treatment or drug resistance. Substantial neurosyphilis in stage III syphilis (e.g., spinal cord consumption, paralytic dementia) may occur in 50% to 80% of patients with serum resistance even after long-term regular anti-syphilis treatment. Early diagnosis, early treatment, and a full course of treatment are the best means of avoiding serum resistance. 5, pay attention to “serum relapse” after receiving insufficient amount of anti-Mei treatment, the serum reaction can turn positive again soon after temporary negative, or the titer increases 4 times (such as from 1:2 to 1:8), which is called “serum relapse”, thus it can be seen that anti-Mei This shows that there is a close relationship between the regularity and adequacy of anti-May treatment and serological relapse.