Neurosyphilis is a series of damages caused by the invasion of syphilis spirochetes into the central nervous system. Symptoms are diverse and vary depending on the site of invasion. For example, if the optic nerve is invaded, it can cause vision loss or blindness; if the voice nerve is invaded, it can cause speech impairment, etc. The diagnosis of neurosyphilis can be confirmed by medical history, clinical symptoms and cerebrospinal fluid examination, as follows: 1. syndrome manifestations, such as hemiplegia, aphasia, epileptic seizures), cerebral parenchymal syphilis (appearing paralytic dementia, spinal cord consumption, etc.), but also asymptomatic neurosyphilis, with only abnormal cerebrospinal fluid findings; some patients with neurological manifestations as the first symptoms; 3, laboratory tests: white blood cell count ≥ 10 × 106/L, protein amount > 500 mg/L, and no other causes of these abnormalities. Positive cerebrospinal fluid VDRL test (or RPR/TRUST test) or FTA-ABS test (or TPPA/TPHA test).