The commonly referred to transaminase refers to glutamic aminotransferase (ALT), which is often elevated in liver damage and is commonly found in various liver diseases, and requires targeted treatment according to specific causative factors. The following treatments are common: 1. liver protection therapy: patients can use appropriate anti-inflammatory, reduce peroxidative damage and other drugs, such as reduced glutathione, glycopyrrolate preparations, dicyclomine, etc.; 2. antiviral therapy: tenofovir, entecavir and other nucleoside analogues and interferon are commonly used for antiviral therapy for hepatitis B. Patients with cirrhosis can also undergo anti-hepatitis virus therapy and treatment for other etiologies; 3. Surgical treatment: patients with severe liver disease can consider artificial liver or liver transplantation. Patients with obese fatty liver whose lifestyle changes are ineffective can be treated by weight loss surgery. Therapeutic resection is one of the most effective methods to treat hepatocellular carcinoma, and patients can also choose radiofrequency ablation and liver transplantation; 4. Other treatments: elevated ALT is the most prominent biochemical abnormality in primary biliary cirrhosis, and the drug of choice is ursodeoxycholic acid, which can be improved in about 90% of patients within 6-9 months. Prednisone in combination with azathioprine is recommended in preference for patients with autoimmune hepatitis, and the treatment regimen needs to be tailored on an individualized basis. In addition, elevated transaminases may also be associated with exertion, alcohol consumption, and obesity. Patients should have a low-fat and low-sugar diet, avoid alcohol, spicy, fried and cholesterol-rich foods, and consume protein and fresh fruits and vegetables. Foods such as garlic, celery, shiitake mushrooms and kelp can help prevent the formation of fatty liver and have certain de-lipidifying effects. Appropriate physical exercise, ensure rest and combine work and rest can help to enhance physical fitness and alleviate the phenomenon of elevated transaminases, which also helps to prevent the disease.