Abdominal symptoms may be minimal or absent during the development of liver disease. Occult pain, swelling, tingling or burning sensations in the upper right abdomen may indicate liver disease, but in most cases the liver is inflamed or congested with only mild pressure pain in the upper right abdomen. Some liver diseases have manifestations of ascites with occasional abdominal distention, but are often not noticed until the abdominal girth increases. Along with the increase in ascites, patients may develop bilateral lower limb edema or even generalized swelling, and these symptoms should be seen as soon as they appear. Spider nevus, liver palm and liver disease face are common manifestations in patients with chronic liver disease. “Spider nevus” is a scattered red dot surrounded by red filaments on the skin surface of the whole body, especially on the face and neck, and when the center of the red dot is gently pressed with a pointed object, the red filaments around it can disappear, but after stopping the pressure, the red filaments come back again; “liver palm” is a congested skin on the surface of the palm of the hand and the end of the finger. The skin of the palm surface is congested and red; “liver disease face” is manifested by the gradual darkening of the facial skin color, the face is dark and lusterless, the skin is dry and rough, and even a “bronze” face, some patients are especially gray around the eyes, as if Some patients have a “panda eyes”, some patients have tiny capillary dilation on the face or nose tip, like a slender network. Once these manifestations are present should be alert to the possibility of chronic liver disease or even cirrhosis, and should be promptly treated at a hospital to avoid delaying the condition. Fat people need to be alert to the occurrence of fatty liver. Long-term greasy diet, lack of exercise, body mass index (BMI) exceeds the standard are “high-risk factors” of fatty liver, so obese people, diabetic patients should be checked annually liver function and abdominal ultrasound, in order to early detection and treatment. Long-term alcohol consumption needs to be guarded against alcoholic liver. Studies have shown that an average daily intake of 80g of ethanol for more than 10 years will develop alcoholic cirrhosis, while the patient may not have any discomfort for a long time. Therefore, it is wise for long-term drinkers to stop drinking in time and go to the hospital as soon as possible for examination. In addition, “it is a medicine that is poisonous”! Anti-tuberculosis drugs, chemotherapy drugs, antipyretic and analgesic drugs, immunosuppressants, hypoglycemic and lipid-lowering drugs and antibiotics may lead to liver damage; recent studies have found that many Chinese medicines and “health care products” and diet pills are causing more and more liver damage. Therefore, if after taking drugs, weakness, epigastric discomfort, poor nausea, vomiting, deepening urine color and even jaundice, etc., should be highly suspected of drug-related liver injury may occur, need to promptly go to the hospital for treatment.