China is a large country with hepatitis B virus infection, many HBV-infected people do not understand the knowledge related to hepatitis B. Once they find out that they are positive for hepatitis B, they are very afraid and desperately want to “turn negative”. Some informal hospitals take advantage of this heart of patients, loudly promote “one shot to turn negative” “package cure hepatitis B, invalid refund”, etc., some media also for these inaccurate advertising, so that many patients have been deceived. So, are all HBV infected people need to be treated, and how should hepatitis B be treated? Adults with acute hepatitis B, more than 90% of them can completely clear the virus and achieve complete cure, so it is not advocated to carry out antiviral treatment early in the infection, but if the HBVDNA is still not negative for more than 3 months and the disease has a chronic trend, antiviral treatment can be given. Infants and children infected with HBV, because the body’s immune system is not yet fully developed, often in the immune tolerance period, although the body has a high level of viral replication but does not develop, and does not require treatment, need regular checkups. For people with chronic HBV infection, the first thing: what should be clarified is the extent of the disease. If you are a hepatitis B virus carrier, you do not need treatment for the time being. You should monitor liver function and HBVDNA and other indicators regularly, and wait for antiviral treatment when liver function abnormalities appear. For patients with chronic hepatitis B with abnormal liver function, antiviral therapy is needed as early as possible to maximize the inhibition of hepatitis B virus replication and to stop disease progression. Current antiviral drugs include two major classes of interferon and nucleoside analogs, and drug selection and treatment follow-up should be performed under the guidance of a medical professional. In the case of patients with cirrhosis, lifelong antiviral therapy is required unless complete clearance of the hepatitis B virus is achieved.