Ankylosing spondylitis has a tendency to run in families, meaning that the disease has a genetic predisposition. Will it be passed on to my children? Will treatment and medication affect fertility? These are often the concerns of patients and their families. Ankylosing spondylitis is a disease of many causes, and genetics is only one of them, not the only factor that affects the disease. This means that if you are an ankylosing spondylitis patient, your child is only 20-30% likely to develop the disease. In some patients with ankylosing spondylitis, even those who are HLA-B27 antigen-positive do not always have children who are positive, and even if their children are positive, they do not necessarily have the disease because about 5% of normal people can be HLA-B27 antigen-positive. It has been reported that the drugs used to treat ankylosing spondylitis, such as sulfasalazine, methotrexate, and rhodopsin, have some effect on the gonads, but they are reversible. It has also been reported that methotrexate has side effects that cause fetal malformations, but they occur mostly after larger dosages, and the total amount of the full course of treatment in the treatment of ankylosing spondylitis does not exceed 1000 mg at most. However, from the perspective of eugenics, the drug should be discontinued six months or more in advance when preparing for childbirth, which generally does not affect the quality of fertility. The actual NSAIDs, such as too much and too long, can inhibit prostaglandin synthesis, so there are sometimes some adverse effects on sexual function, but reversible, and can return to normal after adjustment or discontinuation of the drug. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. Furthermore, depressed mood can also lead to the slowing down of the circulation of all organs in the body and the decrease of resistance, which can easily cause other diseases. Through the resolution of psychological barriers, the correct evaluation of their own disease, the patient’s attitude from negative to positive, the patient’s mood from pessimism to optimism, with the treatment on the passive to active, so that patients with ankylosing spondylitis have a healthy state of mind, with external treatment so that the pathology of the body also towards health.