Chronic hemolysis refers to the process of chronic lysis and destruction of red blood cells in the blood and shortening of their life span. The characteristics of chronic hemolysis are: i. The patient will become anemic because if the rate of hemolysis exceeds the compensatory function of bone marrow, the number of red blood cells in peripheral blood will become less and less, and the patient will show symptoms of anemia, which manifests as pallor, dizziness and weakness, and symptoms such as panic and chest tightness will appear after activity. Second, during physical examination, the patient will have yellow sclera and enlarged liver and spleen. This is because after the destruction of red blood cell lysis, hemoglobin will be released, which will be metabolized by the liver to form bilirubin. If too much red blood cell lysis and destruction exceeds the processing capacity of the liver, too much bilirubin penetrates into the blood, causing an increase in the concentration of bilirubin in the blood, which also deposits on the skin and sclera, causing scleral yellow staining, also called jaundice. At the same time, due to the decrease in the number of red blood cells, the liver and spleen perform compensatory hematopoietic functions, and hepatosplenomegaly may also occur.