To check for intrauterine hemolysis in the fetus, antibody potency can be checked by drawing venous blood from the pregnant woman. If there is an abnormal elevation of antibodies, there is a risk of intrauterine hemolysis in the fetus. Ultrasound can also be used to observe the fetus for edema, such as edema of the skin, pericardial effusion, and fluid in the abdominal or thoracic cavity. Hemolysis is most common in pregnant women with Rh-negative blood whose husbands are Rh-positive or in pregnant women with O blood type whose husbands are of other blood types. Hemolysis also manifests itself as severe jaundice in the newborn after birth, which may cause hepatosplenomegaly, severe anemia, or bilirubin encephalopathy.