Open-eye coma is characterized by the patient’s clear consciousness, but the patient is unable to move his or her eyes except for eye movements, and can follow instructions to open and close the eyes or make eye movements in all directions. However, how much do we know about the clinical manifestations and preliminary diagnosis of open-eye coma? Clinical manifestations Patients appear on the basis of the primary disease, mostly after the coma is treated by resuscitation. Although patients cannot perceive themselves or their surroundings, and cannot communicate and exchange with each other, they can open their eyes or open their eyes under stimulation, and their eyes can move, but they have no consciousness and purposeless movement; there is no activity of the limbs, and they cannot understand or express language, but they resume the sleep-wake cycle; there is no emotional response, and occasionally they can have involuntary shouting, no behavioral response to visual, auditory, tactile or noxious stimuli, and sometimes primitive reflexes when given stimuli. For example, stimulation of the head and neck may be followed by a slow twisting movement of the whole body or part of the body after a short latency period. There is spontaneous respiration, stable blood pressure and pulse, no need to use maintenance measures, but there is incontinence, subthalamic and brainstem functions are basically preserved, cerebral nerve and spinal cord reflexes exist to varying degrees, involuntary chewing movements appear, and there may be sucking reflex and strong grip reflex. The above symptoms lasted for more than 1 month. Diagnosis: 1. loss of cognitive function, no conscious activity, and inability to execute commands; 2. maintenance of voluntary respiration and blood pressure; 3. presence of sleep-wake cycle; 4. inability to understand and express language; 5. ability to open eyes automatically or under stimulation; 6. may have purposeless eye tracking movements; 7. basic preservation of hypothalamic function and brainstem function.