Coma induced by CNS depressants is one of the types of pituitary crisis and pituitary stroke crisis, which is induced by hypopituitary hypoplasia, lack of adrenocorticotropic hormone and thyroid hormone, and decreased stress capacity of the body, in case of infection, vomiting, diarrhea, dehydration, cold, starvation, and application of sleeping pills or anesthetics. Acute neuroendocrine lesions caused by sudden intratumoral hemorrhage, infarction and necrosis of pituitary tumors, resulting in tumor expansion, are called pituitary strokes. The following diseases are also causes of coma induced by CNS depressants: 1. Phosphorus poisoning Poisoning caused by exposure to phosphorus agents. There are acute and chronic. Phosphorus has four isotopes: yellow phosphorus, red phosphorus, purple phosphorus and black phosphorus. Yellow phosphorus, also known as white phosphorus, is the most toxic. Human absorption of up to 1mg / kg can be lethal. Occupational acute poisoning is mostly seen in production accidents, from the molten phosphorus burns the skin, and absorbed into the body to produce poisoning. Daily life can be caused by accidentally taking yellow phosphorus and poisoning. 2, pesticide poisoning Pesticides (pesticide) refers to drugs used to eliminate and control pests, germs, rodents, weeds and other harmful plants and animals that harm crops and regulate plant growth. According to their uses, they can be divided into insecticides, acaricides, nematicides, molluscicides, rodenticides, herbicides, defoliants and plant growth regulators. Pesticides are widely used, of which the most varieties of insecticides and the largest amount. China’s current insecticide dosage of the top four organophosphorus, organochlorine, insecticides and carbamates. 3, pituitary crisis and pituitary stroke When the anterior pituitary gland is hypoplastic, the lack of adrenocorticotropic hormone and thyroid hormone, the body’s stress capacity is reduced, and the crisis is induced by infection, vomiting, diarrhea, dehydration, cold, hunger, etc. and the application of sleeping pills or anesthetics. Acute neuroendocrine lesions caused by sudden onset of intra-tumoral hemorrhage, infarction and necrosis of pituitary tumors, resulting in expansion of the tumor, are called pituitary strokes.