Coma induced by CNS depressants is one of the types of pituitary crisis and pituitary stroke crisis, which is induced by hypopituitary hypoplasia, lack of adrenocorticotropic hormone and thyroid hormone, and decreased stress capacity of the body, in case of infection, vomiting, diarrhea, dehydration, cold, starvation, and application of sleeping pills or anesthetics. Acute neuroendocrine lesions caused by sudden intratumoral hemorrhage, infarction and necrosis of pituitary tumors, resulting in tumor expansion, are called pituitary strokes. 1. Endocrine function measurement: The pituitary gland hormone and the corresponding target gland hormone are reduced at the same time. (1) Decrease in blood target gland hormones and their metabolites (T3, T4, FT3, FT4, TSH, ACTH, P, T, E2, FSH, LH). (2) Gradual increase of target gland hormones after several days of continuous excitation with pituitary prohormones (TSH, CTH, LH) with delayed response can be distinguished from primary hypotensive target gland function. (3) No response to TRH, CRH and LHRH excitation test. (2) X-ray of the pterygoid saddle: The enlargement of the pterygoid saddle can be seen in hypothalamic or pituitary tumors. Microadenoma of the pterygoid saddle is not enlarged but may have limited destruction, CT or MRI can help further diagnosis. 3.Brain Doppler ultrasound (TCD) is a method to examine the brain by brain Doppler ultrasound. Transcranial color Doppler imaging, via temporal window, occipital window, orbital window exploration, can probe the cerebral arteries, according to the intracranial vascular flow velocity, frequency width, flow direction abnormalities or audio abnormalities and other determinations, applied to the diagnosis of cerebrovascular disease and etiological classification. 4.Brain nerve examination There are 12 pairs of brain nerves, which are generally named sequentially with Roman numerals. The first and second pairs of cerebral nerves (olfactory and optic) are the bundles of nerve fibers of their secondary and tertiary neurons in the intracranial part, and the remaining 10 pairs of cerebral nerves are connected with the brainstem, which has its nuclei, with the motor nuclei located near the median line and the sensory nuclei on the lateral side. A portion of the Ⅺ brain nerve pairs (paranerves) emanates from the anterior horn of the upper segments of the cervical spinal cord. The cerebral nerves have sensory and motor fibers and mainly innervate the head and face. The I, II, and VIII pairs are sensory nerves, the III, IV, VI, D, and Ⅻ pairs are motor nerves, and the V, VII, IX, and X pairs are mixed nerves. In addition, pairs III, VII, IX, and X contain parasympathetic fibers. All supranuclear innervation of the motor nuclei of the cerebral nerves is dual innervation except for two pairs (the lower part of the nuclei of the VII and Ⅻ pairs). Cerebral nerve examination is extremely meaningful for the localization and diagnosis of cranial damage. There are 12 pairs of cerebral nerves, and the examination of cerebral nerves should be performed in sequential order to avoid duplication and omission.