1.How should I deal with itchy skin and will scratching aggravate the disease? Patients with ichthyosis often have combined itchy skin, which is caused by the abnormal skin keratinization, resulting in excessive water loss in the skin, and the dry skin is easily stimulated by physical and chemical factors in the environment to induce inflammatory reactions. The itching of the skin is likely to induce scratching reaction, but scratching in turn will aggravate the destruction of the epidermal stratum corneum, resulting in a further decrease of the epidermal water locking capacity, forming a vicious cycle of itching – scratching – itching. Therefore, itching should be actively treated. Conventional treatment includes keeping the environment moist, avoiding overheated environments, avoiding spicy and stimulating foods, avoiding alcohol, and reducing skin contact with alkaline toiletries. When the itching remembered to attack, you can use spiritus, creams containing mint, ice chips, camphor and other drugs to stop itching, and in severe cases, you can take oral antihistamines to help control the itching, ensure the quality of sleep at night and reduce scratching. 2.How many times a day should skin moisturizers be used, only for the affected area or for the whole body? Moisturizers or moisturizing creams are best used every day, and the number of times should be determined by the severity of the rash, the humidity of the environment and the season. In general, the more severe the rash, the drier the environment and the winter months, the more frequently moisturizer can be used and the less frequently. There is no fixed limit to the number of times it can be used, and it is best if the skin does not feel dry and is mildly oily. It is recommended to use mainly on the affected area. 3.Will doing some sports or work that may damage the skin aggravate the condition? Usually, proper exercise and work are possible and will not have much effect on the condition. For example, some severe ichthyosis can be combined with severe keratosis and cracking of the palm and plantar area, so it may not be suitable for mopping the floor or doing household chores which are easy to contact with alkaline chemicals. 4.How many days should a patient take a bath and are there any special requirements for lotions? The number of baths also depends on the severity of the rash, the humidity of the environment and the season. Usually the number of times can be more frequent in summer, while in winter it is recommended to reduce the number of baths. Regardless of the number of times, it is recommended to apply moisturizing lotion to the entire body after bathing. The lotion is best close to the oil layer of the skin. It is recommended that patients maintain a light greasy feeling, but does not affect sweating or does not lead to a dry and itchy feeling of the skin all over the body is appropriate. 5.Does smoking and alcohol have any effect on the disease? Is there any dietary taboo? There is no clear adverse effect of alcohol and tobacco on ichthyosis, but from the medical point of view, it is recommended to reduce the intake of alcohol and tobacco as much as possible. In terms of diet, it is recommended to avoid spicy and stimulating foods. Usually seafood, beef and mutton, milk and eggs can be eaten normally as long as there is no history of allergy. 6.Does sun exposure (ultraviolet radiation) have any effect on the disease? However, unlike psoriasis, ichthyosis does not have a therapeutic response to sunlight or UV light, so it is usually not recommended to treat ichthyosis by sunlight or UV light.