Hepatobiliary stones are stones that occur anywhere within the hepatobiliary system, including gallbladder stones, choledocholithiasis, common hepatic duct stones, intrahepatic choledocholithiasis, and complex site stones. Hepatobiliary stones are a common and frequent disease, and the incidence tends to increase progressively with age. The traditional treatment of hepatic bile duct stones mainly adopts open surgery, but with the maturation of various endoscopic and laparoscopic techniques, minimally invasive surgery has changed the traditional biliary surgery treatment means in China. Due to the complexity of liver and gallstones and the great differences in pathology, it is often difficult to achieve comprehensive treatment results with a single minimally invasive technique. The minimally invasive biliary surgery department of Zhongshan Hospital affiliated to Dalian University adopts a variety of minimally invasive methods and applies them jointly, so that many complex and critical gallstone patients can be effectively treated and recovered. The application of duodenoscopy Dr. Ma Yuefeng introduced that for choledocholithiasis, preoperative duodenoscopic retrograde cholangiopancreatography, sphincter of Oddi incision, endoscopic nasobiliary drainage, etc., to accurately understand biliary pathology and to remove the stones. With duodenoscopic technique, choledochal stones can be removed orally without incision or anesthesia. With the advantages of safety, less pain and repeatability, it is now the preferred choice in international or developed regions. In addition to choledocholithiasis, duodenoscopy has now been extended to the treatment of more than a dozen diseases such as acute severe cholangitis, biliary pancreatitis, papillary sphincter stenosis and dysfunction, etc. Its techniques also include papillary sphincterotomy (EST), mesh basket stone extraction, mesh basket lithotripsy, built-in tubular drainage such as nasocholestial drainage, pancreatic duct endodrainage, etc., as well as balloon and mechanical choledochotomy. The procedure of duodenoscopy is similar to gastroscopy, except that the technique is more advanced and complex. The patient’s feeling is similar to gastroscopy, no obvious pain, usually 3~5 days can be discharged from the hospital, good health conditions, can be outpatient treatment, immediately after the operation down to the ground, treatment can go home the same day. Fiber cholangioscopy application of traditional methods of treatment of hepatic bile duct stones in the postoperative residual stone incidence can be as high as 30% ~ 90%, and has a great blindness and limitations, can cause bile duct injury, biliary bleeding, Odd i sphincter and duodenal injury and other complications. Dr. Ma introduced that fiberoptic choledochoscope is a kind of soft mirror that can be bent at any angle, and it can penetrate into the II, III and even IV branches of intrahepatic bile ducts, and stones can be extracted under the direct vision of choledochoscope. For larger bile duct stones, mechanical lithotripsy, laser lithotripsy, plasma lithotripsy can be used to achieve the effect of completely removing the stone, at the same time, the doctor can clearly observe the changes in the mucosa of the intrahepatic bile ducts through the choledochoscope, and timely detection of cancerous transformation of intrahepatic bile ducts caused by the stone, which is a kind of therapeutic means with the dual function of treatment and examination. Application of percutaneous transhepatic choledochoscopy With the advancement of interventional instruments and the improvement of interventional operation techniques, the minimally invasive biliary surgery department of Zhongshan Hospital affiliated with Dalian University has carried out the treatment of hepatic bile duct stones through interventional techniques. According to Dr. Ma, this technique is based on percutaneous transhepatic puncture biliary drainage, gradually expanding the drainage channel, using choledochoscope combined with modern high-tech lithotripsy, stone extraction equipment and drainage stent for the treatment of hepatic and biliary stones, which has the advantages of simplicity, effectiveness, safety, and repeatable treatment, especially suitable for the elderly and frail, those who are not suitable for or willing to undergo traditional surgery, and those who have a history of multiple surgeries. It is a very effective treatment for hepatobiliary diseases. It is known that percutaneous transhepatic choledochoscopy combined with sphincterotomy (EST) or mechanical lithotripsy can achieve 98.5% of bile duct stone removal rate.