Hepatic artery embolization has been applied to the clinic for more than 20 years, during which a large number of patients with hepatocellular carcinoma have been treated with good therapeutic effects. With the application of embolizing agent iodized oil and the improvement of catheter equipment and intubation technique, the number of patients with long-term survival has gradually increased, and the overall evaluation of the therapeutic effect of hepatocellular carcinoma is partially curable. In order to further improve the therapeutic efficacy of tumor embolization and to overcome the loss of iodized oil during iodized oil embolization which affects the embolization effect, we are looking for a new embolizing agent with better therapeutic efficacy-sodium alginate microsphere vascular embolizing agent. We hope to play a role in improving the therapeutic effect of hepatocellular carcinoma. Materials and Methods From March 2003 to March 2005, 98 cases of 162 patients were embolized with sodium alginate microsphere vascular embolization agent (KMG for short) produced by Beijing Saint-Medicine-Yao Technology Development Co. Steps: puncture through the femoral artery, Seldinger cannulation technique, hepatic arteriography before embolization, super-selective insertion of the catheter into the area where the tumor vessels were located, and insertion into the hepatic left, hepatic right, or a certain hepatic segmental arteries according to the needs. Perfusion chemotherapy and embolization were routinely used. The chemotherapy regimen: THP60mg, mmc 20 mg, 5fu1000mg. chemotherapy was infused first and then embolization was performed. During the whole process of treatment, several angiograms are needed to help judge and guide the dosage of embolic agent according to the changes of tumor vessels, so as to preserve the normal hepatic artery as much as possible while embolizing the tumor vessels. The type of catheter is selected according to the need, conventional contrast catheter and coaxial catheter. Enhanced CT was done before and after the operation to observe the tumor size and necrosis degree; digital subtraction angiography was done to observe the tumor vessels and tumor staining range to evaluate the embolization effect. RESULTS 1. General data: 98 cases in the whole group, 71 males and 27 females, maximum age 78 years old, minimum age 36 years old, 52 people with primary liver cancer, 30 people with liver metastases (16 people with liver metastases from digestive tract tumors, 6 people with liver metastases from postoperative breast cancer, and 8 people with other types (including lung cancer, pancreatic cancer, prostate cancer, malignant thymoma, renal cancer, gynecological tumors). There were 8 patients with hepatic hemangioma and 4 patients with hepatocellular carcinoma combined with hypersplenism; 98 cases were embolized with KMG for 162 times, with the maximum number of embolization being 4 times and the minimum being 1 time. 2, embolization reaction: 53 times of abdominal pain after embolization accounted for 32.7%, 44 cases of mild to moderate accounted for 83%, 9 cases of severe accounted for 16.9%; 70 times of no pain after embolization accounted for 43.2%, 80 times of fever after embolization accounted for 49.3%, 82 times of no fever, generally discharged after three days of embolization, the individual patients with post-embolization pain lasted for 5-10 days, with the degree of mild to moderate, no digestive tract perforation, no digestive tract perforation, no gastrointestinal tract perforation, no gastrointestinal tract perforation, no gastrointestinal tract perforation, no digestive tract perforation, no digestive tract perforation. There was no perforation of the digestive tract, no gastrointestinal bleeding, and no complication of gallbladder necrosis. Postoperative treatment: postoperative symptomatic treatment, including pain relief, hepatoprotection, anti-inflammatory and other treatments. 4. Therapeutic efficacy: from more than 2 times of review cases: enhanced CT showed that the original lesion became low density, the lesion shrinkage was more obvious, the degree of shrinkage was related to the degree of embolization, angiography showed that the hepatic artery was not accessible in most of the cases in the one-month review after microsphere embolization, and the effect of blood flow blockage was better than that of ultra-liquidated iodine oil, most of the cases were obviously shrunken after one time of treatment, and those who had rich blood vessels in the tumor needed to be repeated several times of treatment, and those who had low blood supply in the tumor were obviously better than those who had low blood supply. Those with rich tumor blood vessels need repeated treatments, and those with low blood supply in tumor blood vessels are obviously better than super-liquefied iodized oil. Conclusion: Sodium alginate microspheres are an effective and safe embolizing agent, easy to use, with good therapeutic effect, which can overcome the loss of iodized oil and enhance the effect of embolizing blood vessels to improve the therapeutic effect. It is recommended to promote its use in embolization of tumors.