The main routes of mother-to-child transmission of hepatitis B virus are intrauterine transmission, transmission during labor, and transmission through postnatal feeding. Current data show that direct infection of the fetus through the placenta in utero before delivery is rare, accounting for only 5-10% of cases. Most mother-to-child transmission occurs when the newborn is infected by contact with maternal blood or amniotic fluid during labor and delivery, or by postnatal feeding and close contact. Currently, medical practitioners often use the sequential injection of hepatitis B immunoglobulin for pregnant women in late pregnancy and hepatitis B immunoglobulin and hepatitis B vaccine for newborns immediately after birth to block mother-to-child transmission, and the blockage rate can reach about 90%. Can breastfeeding infect infants? At present, domestic scholars have two opinions on this issue: one is that although there is hepatitis B virus in the mother’s breast milk, but the number of viruses is far from high in the blood, and the hepatitis B virus will not be infected through the digestive tract, the newborn baby 24 hours after birth, the first shot of the vaccine can be breastfeeding. However, mothers should wash their hands with soap and running water before breastfeeding, and those with cracked nipples should temporarily stop breastfeeding and not feed their children mouth-to-mouth to reduce the chance of transmission. Another part of scholars believe that mothers infected with hepatitis B virus are insured by not breastfeeding their children.