What is PSA? PSA is an organ-specific indicator of the prostate gland, and a significant increase in PSA is mainly seen in prostate cancer, so middle-aged and older men with symptoms of prostate enlargement should seek medical attention to control their symptoms and have their PSA checked regularly. Why should I have a prostate puncture biopsy? An elevated PSA indicates a higher chance of prostate cancer, but there is only one gold standard for a definitive diagnosis of early prostate cancer, and that is a prostate puncture biopsy. A prostate puncture biopsy is a pathological examination of the prostate gland using an automated puncture gun under transrectal ultrasound guidance to ensure timely detection of patients with early prostate cancer. For middle-aged and elderly patients with prostate enlargement, PSA should be checked regularly and further prostate puncture should be performed in time to determine whether prostate cancer is present. In the past, a PSA value of more than 4.0 ng/ml was considered an indication for a prostate puncture biopsy, but recently some medical centers in the United States have lowered the standard to 2.5 ng/ml, which requires a prostate puncture biopsy to ensure timely detection of some patients with early prostate cancer. Striving for early detection, early diagnosis and early treatment, patients with early prostate cancer can usually achieve complete recovery after surgical treatment. Patients with prostate cancer that cannot be detected early, on the other hand, often fail to receive timely treatment and lose the opportunity for radical surgery.