Ankylosing spondylitis (hereafter referred to as strong spine) is a chronic inflammatory disease that primarily affects the medial joints, with the sacroiliac joint as the hallmark, and can be associated with a variety of extra-articular manifestations. It is the second most disabling rheumatic disease after rheumatoid arthritis, and in severe cases, spinal deformity and ankylosis can occur, and those with hip involvement can develop claudication. The age of onset is mostly concentrated in 13-40 years old, with more men than women. With the increased awareness and the popularity of advanced detection methods, more and more patients with strong spine are diagnosed early and clearly, which is gratifying, but unfortunately, many patients at a young age already have serious deformities, limited neck bending, hunchback and limp. The reasons for this are: some patients have delayed diagnosis and lost the best time for treatment; a large proportion of patients do not adhere to standard treatment. Ankylosing spondylitis has no specific drugs to date, which determines that treatment of strong spine is a long-term process. The main treatment strategies include: psychological assessment and intervention, pharmacotherapy, local injections, surgery, physical therapy, and exercise rehabilitation. Among them, pharmacotherapy and exercise rehabilitation are the main clinical tools for patients with early diagnosis of strong spine. Medications mainly include NSAIDs, slow-acting drugs such as methotrexate, lorazepam, thalidomide, and leflunomide, and biologic agents. Non-steroidal anti-inflammatory drugs have been the basic drugs for the treatment of strong spine since their introduction in the 1950s. On the one hand, they inhibit the synthesis of prostaglandins, which have a pain-causing effect, by inhibiting cyclooxygenase and thus pain relief. On the other hand, it inhibits neutrophils and inflammatory factors to achieve an anti-inflammatory effect. Many patients only understand its pain-relieving effect and believe that it only treats the symptoms, not the root cause, which is a misconception: the International Society for the Evaluation of Spondyloarthritis (ASAS) still recommends NSAIDs as first-line drugs after weighing the pros and cons. Monitor liver and kidney function after 1 month of treatment and review it once every 3 to 6 months. Drugs taken in the evening are more effective and help to reduce morning back pain and morning stiffness. Methotrexate, lorazepam, thalidomide, and leflunomide are commonly used as disease-modifying drugs, and lorazepam is more effective for combined peripheral joint manifestations. There is no evidence to suggest which one is better, and the response varies from patient to patient. This requires patients to actively and patiently cooperate with their physicians in screening treatment, communicate with their treating physicians immediately after taking any medication, and regularly monitor liver and kidney function. Patients with strong spine are reluctant to move due to pain, and the inflammation erodes the joints, eventually leading to ankylosis of the spine and limited joint movement, which seriously affects the patient’s work life. Therefore, patients are treated with active medication while persevering and strengthening the functional exercise of each joint. Walking, swimming, cycling, climbing, etc. are all suitable forms of exercise, so choose as appropriate and act according to your ability. Although the cause of strong spine is not clear and there is no specific treatment, but like hypertension and diabetes, the condition can be controlled. As long as we overcome anxiety, adjust expectations, face the disease with a calm mind, actively cooperate with doctors medication, persevere, adhere to the exercise, the same and normal people like marriage and childbirth work leisure, life as full of sunshine!