Patients with depression may experience pain symptoms throughout the body, which are non-specific somatic symptoms of depression, including dizziness, headache, scalp tingling, chest tightness, panic, rapid heartbeat, palpitations, shortness of breath, and difficulty breathing. Painful sensations in any part of the body, including shoulders, back, lumbar region, and extremities, including numbness, muscle throbbing sensation, twitching sensation, pain in the chest area, urinary frequency, and urinary urgency. Gastrointestinal discomfort, such as nausea, vomiting, bloating, diarrhea, abdominal discomfort, etc., are all somatization manifestations in depressed patients. And some patients mostly come to the hospital with somatization symptoms as the main complaint, repeatedly. Therefore, for patients who have mainly somatic symptoms, including generalized pain symptoms, and no somatic diseases are found in clinical tests, they should be considered as non-specific somatic symptoms of depression and should be treated with systematic and standardized antidepressant treatment, which is very necessary.