Any disease that can cause hemolysis can produce hemolytic jaundice, the most common being ABO hemolysis, which is caused by a mismatch between the mother’s blood type and that of the fetus. When a child born to an O-positive mother has a rapid rise in bilirubin within 48 hours, for example, a bilirubin value of more than 18 mg/dl, the presence of hemolytic jaundice should be considered. Blue light should be given immediately. This is because the bilirubin value rises rapidly in this type of jaundice, and the high value can easily cause bilirubin encephalopathy by breaking the blood-brain barrier, which can cause serious intellectual and physical behavioral-motor damage to the child. If blue light irradiation is not effective and the bilirubin value continues to rise, the ultimate treatment is blood exchange therapy. In neonates with hemolytic jaundice, if treated in a timely manner, there are usually no other problems and the most serious case is treated with blood exchange, but if not treated in a timely manner, the bilirubin values are extremely elevated, causing bilirubin encephalopathy resulting in this irreversible damage that may cause lifelong disability to the child. Therefore, once the diagnosis is confirmed, the child must be sent to the neonatal unit to give timely symptomatic treatment and not to delay the child’s condition.