Neonatal hemolytic jaundice requires attention, and the degree of neonatal hemolysis is relevant. Neonatal hemolysis is caused by mother-child blood group incompatibility, usually jaundice, anemia, liver and spleen enlargement and other clinical manifestations, and severe bilirubin encephalopathy, death, etc., the severity of the symptoms is basically the same as the degree of hemolysis. 1. Mild hemolysis: if the child is only mild neonatal hemolysis, usually only jaundice, at this time can be blue light therapy, drug therapy and other interventions, the general prognosis is still good. 2. Severe hemolysis: jaundice will increase rapidly, causing cholestasis; at the same time, the bilirubin in the serum is mainly unconjugated, and the rapidly increasing unconjugated bilirubin in the blood can pass through the blood-brain barrier, resulting in central nervous system dysfunction. Without timely intervention and treatment, permanent damage can occur including hand and foot movements, eye movement disorders, hearing impairment, dental enamel hypoplasia, cerebral palsy, and intellectual backwardness. Severe hemolysis may require blood exchange therapy. Children with neonatal hemolytic jaundice need to be seen promptly to determine the cause of the disease and to receive targeted treatment.