Hemolytic disease of the newborn refers to the incompatibility between the mother’s and the child’s blood type, the mother’s body produces blood type antibodies that do not match the antigen of the fetus’s blood type, and these antibodies pass through the placenta and enter the fetus’s body, resulting in immune hemolysis, which is classified into ABO hemolytic disease, RH hemolytic disease and so on. 1. Neonatal ABO Hemolytic Disease: It is a hemolytic disease of the newborn caused by the incompatibility of mother and child’s blood type, usually the mother is type O and the child is type A, B or AB. 2. Neonatal RH Hemolytic Disease: Generally the mother is RH-negative and the father is RH-positive, the newborn may inherit the father’s RH-positive blood type, thus causing neonatal hemolytic disease. In order to avoid the occurrence of hemolytic disease of the newborn, you should do a good job of regular obstetrical examination during pregnancy, and if you find any abnormality after the birth of the newborn, you should deal with it in time.