Hemolytic disease of the newborn is a more common disease of newborns, for such children can grow up and normal children need to be analyzed specifically, such as severe hemolysis may cause bilirubin encephalopathy, which in turn affects the growth and development of the normal child is not the same. Neonatal hemolytic disease refers to the mother and child blood type incompatibility caused by homozygous immune hemolysis, mainly occurs in the mother type O and fetal type A or B, in the newborn period is also more common, clinical jaundice, anemia and so on. For such babies can grow up and normal children need to be combined with the severity of the disease and whether timely intervention and treatment are related, such as jaundice elevated obvious or not yet timely intervention may appear bilirubin encephalopathy, can appear neurological dysfunction and so on, such as the emergence of neurological and cognitive anomalies or hearing impaired abnormalities and other manifestations, and the same as the normal child is not. For those babies who do not develop bilirubin encephalopathy, their development is usually normal later in life, as in normal children, but close monitoring of growth and development is still needed. It is advisable to consult a specialist for a comprehensive diagnosis.