1, the first generation of antidepressants (1) monoamine oxidase inhibitors (MAOI), representative drugs: phenelzine, morclobemide, because of its side effects, and a variety of drug interactions, clinical application has been very little; (2) tricyclic antidepressants (TCAs), representative drugs: amitriptyline, doxepin, clomipramine, drug side effects are mainly the vegetative nervous system and cardiovascular system, clinical application Decrease. 2.Second generation antidepressants Tetracyclic antidepressants, representative drugs: Maprotiline, side effects are similar to tricyclic antidepressants. New antidepressants (1) selective 5-HT reuptake inhibitors (SSRIs), representative drugs: fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, S-citalopram; (2) selective NA and 5-HT reuptake inhibitors (SNRIs), representative drugs: venlafaxine, duloxetine, milnacipran; (3) norepinephrinergic and 5-hydroxytryptaminergic antidepressants. (4) 5-HT2A receptor antagonists and 5-HT reuptake inhibitors (SARIs), representative drugs: trazodone, nefazodone; (5) other: tianeptine, reboxetine, bupropion, neuropeptides, etc.