The current anti-hepatitis B virus drugs can mostly only reduce the number of viruses and cannot completely remove the virus. For many hepatitis B virus-infected patients, the anti-viral is not needed, or the anti-viral effect is very poor, and even drug-resistant strains of the virus will be screened out, leading to more difficult treatment later when needed. Therefore limit some conditions, selected part of the hepatitis B virus infection for antiviral, in order to achieve better results. These conditions include three main ones: 1. chronic hepatitis B virus infection, i.e., surface antigen positive for more than six months, or obvious signs of chronic liver disease (e.g., liver palms, spider nevus, liver disease facies, etc.) found on the basis of excluding other chronic liver diseases; 2. more obvious liver inflammation or (and) fibrosis, such as ALT exceeding the upper limit of normal value by a factor of two, or liver pathology (requiring liver puncture for liver tissue ) showed liver inflammation and/or liver fibrosis score of grade 2 or above; 3. Appropriate HBVDNA level, HBV DNA ≥20,000 IU/mL (equivalent to 100,000 copies/ml) for HBeAg-positive (commonly known as major triple-positive); HBV DNA ≥2,000 IU/mL (equivalent to 10,000 copies/m l ) for HBeAg-negative (commonly known as minor triple-positive or minor di-positive) patients. /m l ). Anti-hepatitis B virus treatment should be given to all hepatitis B virus-infected patients who meet all three of these conditions. And for patients with definite hepatitis B cirrhosis, aggressive antiviral therapy is recommended as long as HBVDNA is detected, regardless of ALT and HBeAg status. It should be noted that ALT elevation due to co-infection with other pathogens or other factors such as drugs, alcohol, immunity, etc. should be excluded before starting treatment, as well as temporary normalization of ALT after application of enzyme-lowering drugs. In some special diseases such as cirrhosis or taking biphenyl structured derivatives, the AST level may be higher than ALT, and the AST level can be used as the main indicator at this time.