The newest and most complete list of Hepatitis C drugs Sofosbuvir, Daclatasvir and Gilead II ever ———— Updated on 2016.2.1 Note: Since I’m not allowed to flag any personal information on the images, all of them have been re-modified again with a personal website used to prevent theft! The pictures may be mutilated! Everyone make do with it! Yan Ming, Department of Thoracic Surgery, Henan Cancer Hospital Some time ago when I was in the United States, a relative asked me to inquire about a special drug for the treatment of Hepatitis C, so that I could buy it for him in the United States, called what “Sofosbuvir”, which is said to be able to cure Hepatitis C, and asked me if I had heard of it. My first reaction at that time was: fake medicine. Because in my impression, Hepatitis C, like Hepatitis B, is mostly incurable, and countless small advertisements in China proclaiming that it can be cured have eventually turned out to be frauds. Then I went online and realized I was wrong! Now there is indeed the latest drug can cure hepatitis C, and the cure rate can reach more than 90%, which is an incredible figure! The company that developed and produced this drug is Gilead in the United States! And this company not only developed Sofosbuvir (Sofosbuvir, commonly known as “Gilead I”), but also subsequently developed Sofosbuvir (sofosbuvir) and Redipasvir (Ledipasvir) composite tablets (commonly known as “Gilead II”), in Europe and the United States. (commonly known as “Gilead II”), which has achieved excellent efficacy in clinical use in Europe and the United States. Gilead is a California-based biopharmaceutical company that has been developing rapidly in recent years. Our laboratory has this company’s experimental projects: for example, we have done a GS0387 project (the specifics of this project will not say more), through this project I learned that the Gilead company on the experimental requirements are very high: all the experimental drugs are used in special test tubes (with a number) placed in a constant-temperature refrigerator, and then taken out of the special solvents within half an hour of solvency, shock, ultrasonic emulsification, and then feed to the rats. Then the drug is fed to the rats. All procedures must be strictly followed, samples of each step of the experiment are left and signed, the company recovers the samples and tests whether they meet the standards, and if they do not meet the standards, they will be traced back to the operator of the experiment! So everyone in the lab is careful to ensure the accuracy and consistency of the experiments. Turning back to the topic, I was a big believer in this company’s products. But I was dumbfounded when I learned the price of Sofosbuvir (Giga Generation) (here is the publicly available information searched on the internet): “In the United States, the Wholesaler Acquisition Cost (WAC) cost of a 28-tablet/bottle pack of Sofosbuvir tablets is$28,000, or$1,000 per tablet, and most patients need to be treated for 12 weeks, or$84,000 in total cost for a course of treatment. ” Gilead has now proposed a system of tiered pricing globally, whereby pricing is based on a country’s per capita gross national income. The company said Sovaldi would cost about$57,000 in the U.K. and about$66,000 in Germany.On March 21, Gilead confirmed that it had agreed to supply the new drug on the Egyptian market, where a course of treatment (12 weeks) with the drug would cost about$900. This price is about 1% of the price in the US market. Egypt has the highest prevalence of the hepatitis C virus in the world. Gregg Alton, executive vice president of Gilead, said in a statement: “Sofosbuvir tablets are priced in India at$300 a bottle (28 tablets), which is the company’s pricing for low-income countries and is similar to that negotiated by the Egyptian government. We hope to manufacture the drug locally with our Indian partners, and higher volumes and continued research and development will lead to further reductions in the selling price of sofosbuvir tablets at a later stage.” I can only laugh at the price of this drug. But being in a top lab in the U.S., I know that every new drug development costs countless amounts of money, from labs to phase III clinics to market, basically hundreds of millions of dollars easily. So drug companies are bound to recover their costs and generate profits at “sky-high” prices. A professor at the Dana-Farber Cancer Institute of Harvard Medical School once gave a lecture and specifically put forward a research conclusion: the increase in drug prices in recent decades (in the U.S.) is an irrevocable fact, because all the R & D and clinical costs are increasing, and these are not the doctors can decide, the doctors may as well just consider which drugs are good for the treatment effect, and do not have to consider the patient’s costs – – efficacy is the most important thing for the patient to care about. -The efficacy of the treatment is the patient’s main concern! This big truthful point of view has of course sparked some strong opposition and controversy. Thoracic oncologist Bruce E. Johnson, MD, “brushed it off” rather than talk about it. Rising drug prices are something that no patient wants to accept, and even in the US many people are unable to receive treatment because of the sky-high prices of drugs (like Chinese health insurance, most insurance policies in the US won’t pay for these expensive new drugs), not to mention the people in China. It would make sense for some people to buy drugs in underdeveloped areas in this situation (of course it may not be legal)! I’ve been looking for a long time for my relatives and found out that there are many kinds of drugs for this treatment of Hepatitis C. In addition to Sofosbuvir (Gigi Generation), there is also Daclatasvir (Daclatasvir) to go with it. There is also Gilead II (Harvoni, Harvoni). There are also more manufacturers, and surprisingly, in addition to the U.S. and Indian versions, there are also Laotian and Nepalese versions (swoon), and even in the case of the Indian version, there are at least four or more manufacturers’ versions, so it’s almost impossible to know what to do. In order to make it less confusing, I will briefly introduce these drugs based on the pictures: First is Sofosbuvir, the following is from Bing search: “(also translated as Sofosbuvir, Sofosbuvir in English, trade name Sovaldi) is a new drug developed by Gilead for the treatment of chronic hepatitis C, which was approved for use in the United States by the U.S. Food and Drug Administration (FDA) on December 6, 2013 by the U.S. Food and Drug Administration (FDA). Drug Administration (FDA) for marketing in the United States, and approved by the European Medicines Agency (EMEA) on January 16, 2014 for marketing in the European Union countries. It is not yet available in China.” Supposedly it can be bought in the US, Hong Kong and Taiwan with a doctor’s prescription (I’m not sure of the exact process). There are several versions of this earliest marketed drug, with the Indian version being the most numerous and common. The one above is the Gilead generation, the US version. The price is about 1000 dollars for one tablet, haha! Supposedly this Mylan manufacturer is one of the companies authorized by Gilead! But really never heard of this company! The one above is made by NATCO, which is most familiar to the Chinese, and is widely available in China for its products such as Erythroxa Trocar Doxycycline! It should be noted that from the packaging, this product does not have any anti-counterfeiting, especially the anti-counterfeiting mark. For details, see another article, “The latest and most complete India Eresa authenticity identification compilation — 201503 update” This is another more common CIPLA (left) and Hetero Strength (right) products The next is Daclatasvir, (English name Daclatasvir) is a new anti-hepatitis C virus drug developed by Schweppes, which is more similar to sofosbuvir in terms of effectiveness and treatment cycle. daclatasvir was launched in Japan and Europe in 2014. It is said to have been marketed earlier as the Laotian version of DACTINNA, and is now also available in various versions in India. Above is the genuine Japanese version of Daclatasvir! I’m not sure about the price, it shouldn’t be cheap! Above this is the Chinese people are most familiar with the production of NATCO CIPLA company products It is said to be the Lao version, the first time I heard that Laos will also produce this latest drug! I can’t produce it in the great country of China? …… Finally, Gilead II (Harvoni, a combination tablet of sofosbuvir (sofosbuvir) + Redipasvir (Ledipasvir)), in addition to the U.S. version, for the time being, there are only a few companies in India with the latest version. Gilead II, the US version. The price is roughly$94,500 for 12 weeks, which translates to roughly$31,500 per month (4 weeks)! NATCO produces Gilead II, the naming is very strange, compared with the first generation of sofosbuvir trade name Hepcinat is just the name of the extra two red letters after the name LP, we must look carefully ah, do not get it wrong ah! CIPLA products, Mylan products, Hetero Strength products? Incepta, never heard of this company 🙂 Finally, a few more photos: Above, you can see that NATCO’s Generation 1 and 2 have similar names, but still look different, so be sure to distinguish them clearly! Taking the wrong medication is no fun! Is everyone getting confused, too much ha!!!! Anyway, I have been dizzy, I think the most contact is the NATCO production, followed by occasional contact with the CIPLA products, the other have never heard of! It should be noted that none of these products have any anti-counterfeiting measures, even the ones made by NATO don’t have the same anti-counterfeiting mark as the ones made by Ezra! The last thing that needs to be clarified is the price, most of these drugs are listed in these few months, especially the Indian NATCO version of Gilead II, which has been listed in India for no more than 2 months, and the situation of asking for a price is supposed to be very common, and I don’t know what the reasonable price is for all of them, with so many products and manufacturers! As for whether there are fake drugs on the market, I don’t know yet. It’s so expensive, I’m sure there will be fakes soon – domestic crooks generally won’t let go of the fat! Let’s all fend for ourselves and spell out our character! Hey, after returning to China often have a feeling: there are so many scammers! Taobao fake goods, phishing sites, bank card fraud, fraudulent phone calls, P2P and guarantee companies run, ATM machine withdrawal scam …… and so on, a variety of everything, simply all-around surrounded you, at any time to be careful! Every morning when I go to work, I pass behind the hospital, I can encounter scammers and a couple of trustees in the name of “guessing the card” to cheat the patient’s family money (most of the rural people). At first there was only a group of people, but now there are three groups of people at the same time to open fraud, arrogant ah! These months of decoration to buy building materials, often encounter shopkeepers openly cheating: the offer is lower than the cost, and then install the time and then substandard. Encountered such a shopkeeper I am turning my head away …… In the United States there are scammers, but rarely encountered in life, the most common is not more than to receive a phone call that you have won a hundred dollars in bonuses ……, in addition to basically have not encountered other scams. Both the number of scammers and the method of scamming are much less than in the country. The key is that there are basically no fake or shoddy goods in the United States, which is the most reassuring place for people! There is nothing more exhausting for Chinese people than this …… Solemnly declared: the above information is only a personal feeling of the essay. Most of the pictures are from the Internet, which I obtained through various channels, and thanks to the friends who provided the photos! Please contact me to remove any infringement of the above text and images. Vomiting, all pictures are watermarked. Support the original, please indicate the source when reproduced! I specialize in general thoracic surgical oncology and have only a general knowledge of hepatitis diseases and cannot offer any treatment advice! All medical diagnosis and treatment must be combined with the patient’s various tests by the patient’s supervising physician to make a decision! The above information is only to provide the latest information for the majority of patients to avoid confusion, and is not a purchase recommendation. Patients should choose the appropriate treatment plan according to their own condition and economic conditions under the advice of the doctor, I again strongly recommend going to a regular hospital to receive standardized treatment.