Side effects of the new generation of SNRI antidepressants? The current latest generation of antidepressants have undergone rigorous clinical trials and not only have a high rate of clinical recovery, but all side effects are kept to a minimum, even if rare, and are stated as openly as possible. Common side effects include gastrointestinal reactions, such as nausea, dry mouth, constipation, fatigue, drowsiness, excessive sweating, and decreased appetite. Individual drugs have an effect on blood pressure; duloxetine (Cymbalta) has no effect on blood pressure. Side effects mostly appear within a week, and in general, the side effects are basically relieved or disappear after 1 week, if the side effects are obvious you should inform your doctor in time.