There are three basic methods of treatment for having depression: First, the preferred treatment is pharmacotherapy, which is also the preferred treatment measure for patients with moderate and severe depression. The first-line antidepressants with evidence-based medical evidence are mainly 5-hydroxytryptamine reuptake inhibitors, such as escitalopram, paroxetine, sertraline, fluoxetine, venlafaxine, duloxetine, mirtazapine and other drugs. Second, psychotherapy, psychotherapy is especially suitable for depressed patients with obvious psychosocial factors, through supportive psychotherapy, cognitive behavioral therapy, family therapy, psychodynamic therapy, interpersonal relationships and other treatment methods can achieve good results. At present, cognitive-behavioral therapy is socially recognized as a more effective treatment for depression. Third, physical therapy, in the process of clinical treatment, physical therapy is also applicable to depression treatment methods, such as transcranial magnetic stimulation, convulsion-free electroconvulsive system treatment can achieve good results.