Depakene belongs to the emotion stabilizer, for depression treatment is not as the drug of choice, depression preferred treatment drugs are pentraxin reuptake inhibitors, such as sertraline, fluoxetine, paroxetine, citalopram, escitalopram, venlafaxine, duloxetine, mirtazapine and other treatment, in the process of treatment to achieve sufficient amount of full course of systematic standardized treatment, which is very critical. Psychotherapy and physiotherapy need to be recommended as an adjunct, including cognitive behavioral therapy to improve the patient’s irrational cognitive patterns, challenge the patient’s cognitive irrational beliefs and rebuild the cognitive system, and physiotherapy with transcranial magnetic stimulation and non-convulsive electroconvulsive therapy. Depakene is a sodium valproate extended-release tablet, mainly due to the treatment of bipolar disorder, as an emotion stabilizer to prevent bipolar disorder because of the drug occurs to turn to control the condition, so in the case of Depakene, the treatment of simple depression is not recommended clinically.