Some people say that stroke is the number one disease in neurology, but if we look at the number of patients, there is no doubt that the number of patients with headache is the highest. Headache is not a disease, but a symptom. There are many causes of headache, including neurology, psychiatry, internal medicine, otorhinolaryngology, ophthalmology, neurosurgery, orthopedics and other departments. The key to treating headache is to find the cause, or else it will really become “treating the head when it hurts and treating the foot when it hurts”. However, because there are so many causes of headache, it is not easy to find the cause, and its diagnosis and treatment are very complicated, even more than stroke, so “headache” has become the most headache for neurologists. First, according to the diagnostic classification of the International Headache Society, there is no so-called “vascular headache”, “neurogenic headache” or “vascular-neurogenic headache”. First, according to the diagnostic classification of the International Headache Society, there is no such diagnosis as “vascular headache”, “neurogenic headache” or “vascular neurogenic headache”. Secondly, headache is rarely caused by cerebrovascular disease. Since the brain has no pain-sensitive structures, the so-called “lacunar cerebral infarction”, “cerebral white matter demyelination”, “cerebral blood supply deficiency”, etc. are not The so-called “lacunar cerebral infarction”, “cerebral white matter demyelination”, “cerebral hypoperfusion”, etc. are not possible causes of headache. According to the etiological diagnosis of the International Headache Society, there are three major categories of headache: primary headache, secondary headache, and neuralgia (note that it is not “neuropathic headache”). Secondary headaches are headaches that have a clear etiology and an underlying organic lesion. This organic pathology includes both systemic diseases such as hypertension, local diseases such as glaucoma, sinusitis, temporal arteritis, and intracranial diseases such as tumors, hemorrhage, meningitis, meningeal cancer, etc. In contrast, primary headache has an incomplete understanding of the etiology and pathogenesis, and is not based on organic lesions. Primary headache is very common in clinical practice and includes “migraine”, “tension headache”, “cluster headache” and “unclassifiable primary headache”. The most common type of headache is tension headache, which accounts for about 1/3 to 1/2 of all headache patients, followed by migraine. The diagnosis of headache is very complex and requires a specialist neurologist. However, there are a few rules for patients’ reference: 1 Headaches with a long history are usually not a major problem, and if the headache history is more than one year, it is usually not caused by a serious organic disease.2 Migraines are not all migraines; 40% of migraines are bilateral; in contrast, most migraines are not migraines. 3 With the accelerated pace of life and increased stress, tension headaches caused by anxiety are increasing in number and are seen in all age groups. 4 If there is a short history or recent change in the degree and frequency of headache, and there is no other explanation, such as fever or hypertension, then it is important to pay attention to secondary headaches caused by organic diseases and to promptly see a doctor for a detailed examination. 5 Some patients often take pain-relieving drugs after headache, such as Fenbendazole, etc. Long-term use of such drugs can lead to drug-dependent headache, or even to chronic daily headache, so do not abuse painkillers. Our goal is to have a healthy life without “headache”!