Mouth ulcers are one of the main symptoms of leukoaraiosis, often mistaken for ordinary mouth ulcers and delayed diagnosis and treatment, the difference between the two mainly has the following points: 1, leukoaraiosis mouth ulcers occur repeatedly and often more serious than ordinary mouth ulcers, and can not be completely relieved by taking vitamin supplements and trace elements or pay attention to oral hygiene; 2, leukoaraiosis in addition to recurrent mouth ulcers, but also In addition to recurrent oral ulcers, leukoaraiosis can also be accompanied by a variety of symptoms, such as recurrent genital ulcers, eye damage, such as recurrent uveitis, retinal vasculitis, skin damage, such as pseudofolliculitis, erythema multiforme, etc. The disease can also produce corresponding symptoms by involving other systems, while ordinary oral ulcers do not produce damage to other systems; 3. The antibody test related to common mouth ulcers is mostly negative. When ordinary oral ulcers recur, it is difficult to distinguish them from patients with leukoaraiosis who only show oral ulcers at the beginning, so the vigilance of patients and doctors should be raised. Patients with recurrent oral ulcers should improve relevant examinations for clear diagnosis, and timely detection of leukoaraiosis and intervention can relieve patients’ pain and slow down the progress of the disease.