What drugs can cause liver damage? The liver is not only an important organ for the body to process normal metabolites in the body, but also an organ for the transformation (or detoxification) of most drugs, so the relationship between drugs and the liver is very close. Many drugs have direct or indirect toxicity to the liver, such as the use of such drugs for too long, too high a dose, or the organism belongs to the idiosyncratic patients, all have the potential to cause liver damage. For patients with poor liver function, the danger is even greater. Therefore, understanding which drugs can cause liver damage is an important issue in clinical drug use. Some drugs are directly toxic to hepatocytes and damage all structures of hepatocytes without selectivity; some drugs initially only interfere with a metabolic process in hepatocytes, and only later indirectly contribute to hepatocyte steatosis or necrosis; there are also drugs that cause liver damage only in some individuals and belong to a metabolic reaction (immune response) of the body, through antigen (drugs are mostly semi-antigens ) antibody binding, interfering with the structure and function of hepatocytes. According to the pathological manifestations of the liver, drug-related liver damage is generally classified into three types, namely hepatocellular, bile duct obstruction and hepatocellular bile duct type. After the occurrence of liver damage, the clinical manifestation of liver enlargement, liver function abnormalities or accompanied by jaundice. If the drug can be discontinued in time, most of the patients can return to normal; very few patients can further deteriorate and develop secondary hepatic sclerosis. Drug-related liver damage is most common in hepatocellular lesions. Some of the drugs that can cause liver damage are listed below for reference when using drugs: general anesthetics: chloroform, halothane, ethanol. Sedative and antipsychotic drugs: chloral hydrate, paraldehyde, chlorpromazine, endorphin, trifluoperazine, phenelzine, nilamis, phencyclidine, promethazine. Anti-epileptic drugs: phenytoin sodium, mebendazole (methotrexate), benzodiazepine, etanercept. Antipyretic and anti-arthritic drugs: Pautazone, paracetamol, cinchofen, propoxur. Acting on the cardiovascular system drugs: methyldopa, eugenol, antamine, nicotinic acid, procainamide. Diuretics: dihydrocoumaric acid, cyclopentathiazine, diuretic acid. Drugs affecting the endocrine system: methyltestosterone, testosterone propionate, nandrolone phenylpropionate, methylsulfoximine, propylthioxypyrimidine, tapazole. Sulfonamides, antibiotics: sulfadiazine, sulfamethoxine, tetracycline, aureomycin, oxytetracycline, chloramphenicol, erythromycin, ampicillin, carbenicillin, penicillin, ethoxymonoglutethimycin, neomycin, lincomycin, vincristine, rifampicin, ashwagandha, disulfiramycin B. Anti-tuberculosis drugs: isoniazid, para-aminosalicylic acid, pyrazinamide, ethionamide, cycloserine. Anti-parasitic drugs: chloroquine, potassium antimonate tartrate, arsenofanamine, tetrachloroethylene, carbon tetrachloride, DDT, hexahydroxamate. Anticancer drugs: cyclophosphamide, nitrogen mustard phenylbutyrate, aminoglutethimide, azathioprine, nongeridine, methylbenzylhydrazine. What are the common factors affecting drug hepatotoxicity? 1.Dose of drugs: Generally, the higher the dose of drugs with direct toxicity to liver cells, the more serious the liver damage. 2.Application period: Some drugs cause liver damage related to the duration of drug use, for example, liver damage caused by isoniazid occurs more than 3 months after drug use. 3, age: Generally, the elderly are prone to drug hepatotoxicity, mainly because the activity of microsomal enzyme system in liver cells is reduced, and the metabolism ability of certain drugs is reduced. Older people often use a variety of drugs together, drugs interfere with each other. Some drugs are mainly excreted by the kidneys, and the glomerular filtration of the elderly is often reduced, reducing renal excretion, which may cause an increase in the blood concentration of drugs, in addition to compensatory bile excretion. In addition, there are many unknown factors that can make the elderly more prone to drug hepatotoxicity. 4, gender: drug-related liver damage caused by specific metabolic reactions are mostly seen in women. 5, nutritional status: nutritional deficiencies, especially protein deficiencies, can reduce the protective molecules in the liver, such as glutathione, increasing the susceptibility of the body to drug hepatotoxicity. 6, the original disease of the liver: such as hepatic sclerosis patients on the metabolism of many drugs are reduced, so that drugs are easy to accumulate in the liver, resulting in liver damage. Liver disease patients with severe impairment of liver function are often particularly sensitive to general doses of sedative drugs (such as morphine drugs), and can even induce hepatic encephalopathy. What are the principles of treatment for drug-related hepatitis? 1.Immediately discontinue the use of drugs that are damaging to the liver. 2.General treatment is the same as other causes of acute and chronic hepatitis, such as timely rest, give high-calorie, high-protein diet, if there is bleeding, liver coma should be treated as bleeding, liver coma. 3, supplement B vitamins and vitamin C, with a tendency to bleeding plus vitamin K. 4, try to use agents with special therapeutic effects, such as isoniazid-induced hepatitis can be used in larger doses of vitamin B6 static point. 5, with allergies, deep jaundice, serious condition, available adrenal glucocorticoids, to be reduced gradually after the condition. 6, cholestasis type of patients apply phenobarbital and biliary amine treatment, jaundice heavy patients available Chinese medicine gardenia yellow treatment.