There is a wide variety of drug-induced liver damage, including prescription drugs, over-the-counter drugs, nutritional supplements, and herbal medicines. 45% of patients with drug-induced liver damage are caused by a single cause represented by antibiotics, and 20% of patients with drug-induced liver damage are caused by more than one potential hepatotoxic factor. Recently, drug-related liver damage has received increasing attention from medical personnel, and clinical reports are increasing year by year, mostly acute drug-related liver damage, drug-related liver damage also includes chronic drug-related liver damage, which is more diverse, should not be detected in the early stage, generally not taken seriously and easy to ignore, but if it can be identified early, the lesion can be reversed after discontinuing the drug. The hepatotoxicity of drugs can generally be divided into two categories: predictable and non-predictable. Clinically, drug-related liver disease is mostly caused by non-predictable hepatotoxic drugs, which do not have obvious drug dose-effect relationships and are drug metabolites (or drugs themselves) that act directly on liver cells or cause lesions through immune mechanisms. Autoantibodies are not an etiologic manifestation of autoimmune reactions, but may be present in acute and chronic liver diseases, and autoantibodies are not the cause of liver damage, but are a consequence of liver damage. Some chronic drug-related liver damage should not be detected in the early stage, with the onset of acute liver damage. Some patients in this group may have recurrent liver function abnormalities although they have stopped taking drugs, which makes diagnosis difficult for doctors. The mean value of globulin in chronic liver damage was higher than that in acute cases, but not higher than the upper limit of normal value. The presence of high titer autoantibodies seems to suggest the possibility of chronicity. High titer autoantibodies do not necessarily mean that the disease is necessarily autoimmune liver disease, which needs to be combined with clinical and medication history, but should be alert to the development of autoimmune hepatitis, and early liver tissue biopsy can help in the diagnosis. The clinical manifestations of drug-induced chronic liver damage vary in severity, and some drugs can cause moderate to severe chronic hepatitis, with clinical manifestations similar to autoimmune hepatitis.